Abstract

Six new squalene derived polyether glycosides, onygenaleosides A-F (1-6), that possess a 6/5 bicyclic fused ring skeleton were isolated from the cultures of Onygenales sp. YX1425, along with two known analogues (7 and 8). The planar structures of the new compounds were elucidated based on analysis of NMR and MS spectroscopy data, and the absolute configuration of 1 was determined by the advanced Mosher method and quantum chemical calculations. Compound 2 was active against Spodoptera frugiperda with an LC₅₀ value of 193.4 ± 1.1 μg/mL.

Journal of Natural Products, 20 Nov 2023, 86(12):2621-2629，IF=5.1

https://doi.org/10.1021/acs.jnatprod.3c00243